Introduction

  • MD. PhD. 성필수
    가톨릭대학교 의과대학 / 소화기내과 / 면역학 / 02-3147-8737
    • 학력

    • 2012-2016 한국과학기술원(KAIST)이학 박사
      2009-2011 가톨릭의대 의학 석사
      2001-2007 가톨릭의대 의학 학사
    • 경력

    • 2025- 교수, 서울성모병원 소화기내과
      2022-2025 부교수, 서울성모병원 소화기내과
      2020-2022 조교수, 서울성모병원 소화기내과
  • 논문
    업적

    • 2025
    • Dynamic Peripheral T-Cell Analysis Identifies On-Treatment Prognostic Biomarkers of Atezolizumab plus Bevacizumab in Hepatocellular Carcinoma LIVER CANCER
      The PNPLA3 I148M variant is associated with immune cell infiltaration and advanced fibrosis in MASLD: a prospective gentoype-phenotype study JOURNAL OF GASTROENTEROLOGY
    • 2024
    • Intrahepatic immunoglobulin a complex induces polarization of cancer-associated fibroblasts to matrix phenotypes in the tumor microenvironment of hepatocellular carcinoma HEPATOLOGY
      Expansion of effector regulatory T cells in steroid responders of severe alcohol-associated hepatitis LIVER TRANSPLANTATION
      Chitinase 1: a novel therapeutic target in metabolic dysfunction-associated steatohepatitis FRONTIERS IN IMMUNOLOGY
      Prognostic significance of combined PD-L1 expression in malignant and infiltrating cells in hepatocellular carcinoma treated with atezolizumab and bevacizumab FRONTIERS IN IMMUNOLOGY
      Chronic Hepatitis B Genotype C Mouse Model with Persistent Covalently Closed Circular DNA VIRUSES-BASEL
    • 2023
    • Intrahepatic infiltration of activated CD8+ T cells and mononuclear phagocyte is associated with idiosyncratic drug-induced liver injury FRONTIERS IN IMMUNOLOGY
    • 2022
    • Intrahepatic inflammatory IgA + PD-L1 high monocytes in hepatocellular carcinoma development and immunotherapy JOURNAL FOR IMMUNOTHERAPY OF CANCER
      Acute Budd-Chiari syndrome with thrombotic thrombocytopenia after BNT162b2 mRNA vaccination LIVER INTERNATIONAL
      Crosstalk between tumor-associated macrophages and neighboring cells in hepatocellular carcinoma CLINICAL AND MOLECULAR HEPATOLOGY
      Immune-mediated liver injury represented as overlap syndrome after SARS-CoV-2 vaccination
      JOURNAL OF HEPATOLOGY
      Multiplexed Digital Spatial Protein Profiling Reveals Distinct Phenotypes of Mononuclear Phagocytes in Livers with Advanced Fibrosis CELLS
      MiR-23b-3p suppresses epithelial-mesenchymal transition, migration, and invasion of hepatocellular carcinoma cells by targeting c-MET HELIYON
      Tenofovir alafenamide alleviates nonalcoholic steatohepatitis in mice by blocking the phosphorylation of AKT in intrahepatic mononuclear phagocytes BIOMEDICINE & PHARMACOTHERAPY
    • 2021
    • Targeted Next-Generation Sequencing of Plasma Cell-Free DNA in Korean Patients with Hepatocellular Carcinoma ANNALS OF LABORATORY MEDICINE
    • 2020
    • EpCAM-high liver cancer stem cells resist natural killer cell-mediated cytotoxicity by upregulating CEACAM1 JOURNAL FOR IMMUNOTHERAPY OF CANCER
      IFNL3-adjuvanted HCV DNA vaccine reduces regulatory T cell frequency and increases virus-specific T cell responses JOURNAL OF HEPATOLOGY
      microRNA-99a Restricts Replication of Hepatitis C Virus by Targeting mTOR and De Novo Lipogenesis VIRUSES-BASEL
      Infiltration of T Cells and Programmed Cell Death Ligand 1-expressing Macrophages as a Potential Predictor of Lenvatinib Response in Hepatocellular Carcinoma 대한간암학회지(JOURNAL OF LIVER CANCER)
    • 2019
    • Ex vivo Detection and Characterization of Hepatitis B Virus-Specific CD8(+) T Cells in Patients Considered Immune Tolerant FRONTIERS IN IMMUNOLOGY
    • 2017
    • IFN-lambda 4 potently blocks IFN-alpha signalling by ISG15 and USP18 in hepatitis C virus infection SCIENTIFIC REPORTS
    • 2016
    • Immune responses and immunopathology in acute and chronic viral hepatitis nature reviews immunoogy
    • 2015
    • Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness PNAS
    • 2014
    • Hepatitis C virus entry is impaired by claudin-1 downregulation in diacylglycerol acyltransferase-1-deficient cells journal of virology
    • 2011
    • Frequency of Killer Cell Immunoglobulin-like Receptors (KIRs) in Korean Patients with Chronic HCV Infection JOURNAL OF KOREAN MEDICAL SCIENCE